We have been working with custom pulsed UV solid state lasers as excitation sources for the multi-photon ionization of small molecules. We have implemented  compact CW laser sources in the visible and infrared for the vibrational and fluorescence spectroscopy from affinity assays for receptor molecules. We can employ the latest microchip laser resonator technology from our photonic sources in biochip analytical schemes requiring fluorescence excitation or laser desorption ionization of the target analyte. We can implement these photonic probing tools in existing microfabricated devices, such as a chip diagnostic system for immunoassay monitoring, and a benchtop mass analyzer used in applications, such as the screening of candidate biologics for therapeutics.