We have been working with hybrid structures such as gold nanoparticles embedded in polymer films to amplify the bioluminescent  sensing for certain receptor molecules. We have already used surface enhancement in scattering from nanoparticles in Raman microscopy for amplified confocal imaging. We can selectively tune these nanoparticles to a specific size and implement them through bottom up assembly technologies to other substrates for microarray applications. We can also functionalize the surfaces with different ligands to act as nanoprobes. These nanoparticle bioconjugates would exhibit the specified size for targeting of other biomarkers such as DNA and for enhanced emission profiles using optical excitation.